Song Ji-Zheng, Li Ling-Jun, Ji Li, Shun Li, Rui Yan
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
Biomed Rep. 2017 Jan;6(1):113-119. doi: 10.3892/br.2016.810. Epub 2016 Nov 15.
The aim of the study was to examine the effect of complex prescription on the pharmacokinetics of baicalin, rhynochophylline and gastrodin in Tiangou antihypertensive capsule. After administration, rat plasma was collected at different time-points. High-performance liquid chromatography was used to determine the content of baicalin, rhynochophylline and gastrodin in plasma. Two peaks occurred in the baicalin concentration-time curve. No significant difference was found for the peak concentration time (t) and area under concentration-time curve (AUC) of baicalin between the complex prescription and baicalin groups. The peak concentration (C) of baicalin in the complex prescription group was significantly decreased, while no significant difference was found for the absorption factor (K) and AUC of baicalin between the complex prescription and gastrodin groups. The elimination factor (K) of gastrodin in the complex prescription group was significantly decreased, while the apparent volume of distribution (Vd) of gastrodin was significantly increased. No significant difference was found for AUC of baicalin between the complex prescription and rhynochophylline groups. Levels of K and K of rhynochophylline were lower in the complex prescription group while Vd was higher. Thus, complex prescription made plasma concentration-time curve more smooth. By contrast, the Tiangou antihypertensive capsule improved the distribution of baicalin, rhynochophylline and gastrodin .
本研究旨在考察复方对天麻钩藤降压胶囊中黄芩苷、钩藤碱和天麻素药代动力学的影响。给药后，于不同时间点采集大鼠血浆。采用高效液相色谱法测定血浆中黄芩苷、钩藤碱和天麻素的含量。黄芩苷浓度-时间曲线出现两个峰。复方组与黄芩苷组黄芩苷的达峰时间（t）和浓度-时间曲线下面积（AUC）无显著差异。复方组黄芩苷的峰浓度（C）显著降低，而复方组与天麻素组黄芩苷的吸收因子（K）和AUC无显著差异。复方组天麻素的消除因子（K）显著降低，而天麻素的表观分布容积（Vd）显著增加。复方组与钩藤碱组黄芩苷的AUC无显著差异。复方组钩藤碱的K和K水平较低，而Vd较高。因此，复方使血浆浓度-时间曲线更平滑。相比之下，天麻钩藤降压胶囊改善了黄芩苷、钩藤碱和天麻素的分布。
