Caobelli Federico, Bengel Frank M
Klinik für Nuklearmedizin, Hannover Medical School, Hannover, Germany.
Cardiovasc Diagn Ther. 2014 Dec;4(6):412-5. doi: 10.3978/j.issn.2223-3652.2014.12.01.
Although coronary angiography is the gold standard for assessing coronary artery disease (CAD), there is at best a weak correlation between degree of stenosis and the risk of developing cardiac events. Plaque rupture is the most common type of plaque complication, accounting for about 70% of fatal acute myocardial infarctions or sudden coronary deaths. Recently, the feasibility of (18)F-fluoride PET/CT in the evaluation of atherosclerotic lesions was assessed. Radionuclide techniques allow non-invasive biologic assessment of atherosclerotic plaques. This may help to further shift the clinical paradigm in coronary disease away from anatomy toward causative physiology and biology.
尽管冠状动脉造影是评估冠状动脉疾病（CAD）的金标准，但狭窄程度与发生心脏事件的风险之间充其量只有微弱的相关性。斑块破裂是最常见的斑块并发症类型，约占致命性急性心肌梗死或心源性猝死的70%。最近，评估了（18）F-氟化物PET/CT在评估动脉粥样硬化病变中的可行性。放射性核素技术可对动脉粥样硬化斑块进行非侵入性生物学评估。这可能有助于进一步将冠心病的临床范式从解剖学转向致病生理学和生物学。
