Yildirim Yusuf, Olcucu Onur, Agca Alper, Karakucuk Yalcin, Alagoz Nese, Mutaf Cagri, Demirok Ahmet, Kutlubay Zekayi
*Department of Ophthalmology, Beyoglu Eye Research and Education Hospital, Istanbul, Turkey; †Department of Ophthalmology, Istanbul Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey; and ‡Department of Dermatology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Cornea. 2015 Mar;34(3):313-7. doi: 10.1097/ICO.0000000000000350.
To compare the topographic and biomechanical properties of corneas in the eyes of patients with ocular rosacea (OR) with those of healthy individuals.
Thirty-four healthy individuals (control group) and 34 patients with OR (study group) were evaluated in this study. Topographic measurements including keratometry values, irregularity, and surface asymmetry index in the right eye of each participant were obtained using a Scheimpflug camera with a Placido disc topographer (Sirius). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOP), and Goldmann-related IOP were measured using the Reichert Ocular Response Analyzer. Central corneal thickness was also measured using ultrasonic pachymetry and the Sirius corneal topography system.
Topographic parameters were not significantly different between the groups (P > 0.05). Mean CH and CRF were significantly lower in patients with OR (P = 0.003 and 0.001, respectively). Central corneal thickness was significantly lower in patients with OR compared with healthy controls (P < 0.001). Mean Goldmann-related IOP and corneal-compensated IOP were not significantly different between the groups (P = 0.09 and 0.13, respectively).
This study demonstrated that although the eyes of patients with OR had corneal topographic findings similar to those of healthy controls, corneal biomechanical measurements (CH and CRF) were significantly lower in patients with OR. These results need to be considered when planning corneal refractive surgery in patients with OR.
比较眼部酒渣鼻（OR）患者与健康个体角膜的地形学和生物力学特性。
本研究评估了34名健康个体（对照组）和34名OR患者（研究组）。使用带有Placido盘地形图仪（Sirius）的Scheimpflug相机获取每位参与者右眼的地形测量数据，包括角膜曲率值、不规则度和表面不对称指数。使用Reichert眼反应分析仪测量角膜滞后（CH）、角膜阻力因子（CRF）、角膜补偿眼压（IOP）和Goldmann相关眼压。还使用超声测厚法和Sirius角膜地形图系统测量中央角膜厚度。
两组间地形学参数无显著差异（P>0.05）。OR患者的平均CH和CRF显著更低（分别为P = 0.003和0.001）。与健康对照组相比，OR患者的中央角膜厚度显著更低（P<0.001）。两组间平均Goldmann相关眼压和角膜补偿眼压无显著差异（分别为P = 0.09和0.13）。
本研究表明，尽管OR患者的角膜地形学表现与健康对照组相似，但OR患者的角膜生物力学测量值（CH和CRF）显著更低。在为OR患者规划角膜屈光手术时需要考虑这些结果。
