用于测量中央角膜厚度的Sirius Scheimpflug - Placido与超声测厚法：荟萃分析
Sirius Scheimpflug-Placido versus ultrasound pachymetry for central corneal thickness: meta-analysis.
作者信息
Jin Yili, McAlinden Colm, Sun Yong, Wen Daizong, Wang Yiran, Yu Jinjin, Feng Ke, Song Benhao, Wang Qinmei, Chen Shihao, Huang Jinhai
机构信息
School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, UK.
出版信息
Eye Vis (Lond). 2021 Feb 18;8(1):5. doi: 10.1186/s40662-021-00227-5.
BACKGROUND
To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP).
METHODS
A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements.
RESULTS
A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was -11.26 μm with a 95% confidence interval (CI) (-16.92 μm, -5.60 μm). The heterogeneity was I = 60% (P = 0.004).
CONCLUSION
CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.
背景
比较旋转式Scheimpflug相机联合Placido盘角膜地形图仪（Sirius，CSO，意大利）与超声测厚法（USP）测量正常眼中央角膜厚度（CCT）的差异。
方法
对从创刊至2019年8月1日在PubMed、Medline、EMBASE、Cochrane图书馆和ClinicalTrials.gov上发表的相关研究进行系统文献检索。主要结局指标是Sirius和USP之间的CCT测量值。采用随机效应模型汇总CCT测量值。
结果
本荟萃分析共纳入12项研究，涉及862只眼。荟萃分析发现Sirius和USP之间的CCT测量值在统计学上有显著差异（P < 0.0001）。Sirius和USP之间的平均差异为-11.26μm，95%置信区间（CI）为（-16.92μm，-5.60μm）。异质性I = 60%（P = 0.004）。
结论
使用Sirius Scheimpflug-Placido地形图仪测量的CCT在统计学上显著低于USP。然而，可能有人认为11.26μm的平均差异在临床上并无显著意义。
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