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Classification of CEBPA mutated acute myeloid leukemia by GATA2 mutations.

作者信息

Marceau-Renaut Alice, Guihard Soizic, Castaigne Sylvie, Dombret Hervé, Preudhomme Claude, Cheok Meyling

机构信息

U837, INSERM, Lille, France; Hematology Laboratory, Biology and Pathology Center, Lille University Hospital, Lille, France.

出版信息

Am J Hematol. 2015 May;90(5):E93-4. doi: 10.1002/ajh.23949. Epub 2015 Feb 17.

DOI:10.1002/ajh.23949
PMID:25611491
Abstract
摘要

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Classification of CEBPA mutated acute myeloid leukemia by GATA2 mutations.通过GATA2突变对CEBPA突变型急性髓系白血病进行分类。
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GATA2 mutations in patients with acute myeloid leukemia-paired samples analyses show that the mutation is unstable during disease evolution.急性髓系白血病患者的GATA2突变——配对样本分析表明，该突变在疾病演变过程中不稳定。
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GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis.GATA2突变在伴有双等位基因CEBPA突变的中危核型急性髓系白血病中很常见，且与良好预后相关。
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CEBPA single mutation can be a possible favorable prognostic indicator in NPM1 and FLT3-ITD wild-type acute myeloid leukemia patients with intermediate cytogenetic risk.CEBPA 单突变可能是中危细胞遗传学核型伴有 NPM1 和 FLT3-ITD 野生型急性髓系白血病患者的有利预后指标。
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Clinical impact of GATA2 mutations in acute myeloid leukemia patients harboring CEBPA mutations: a study of the AML study group.伴有CEBPA突变的急性髓系白血病患者中GATA2突变的临床影响：AML研究组的一项研究
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Blood Cancer J. 2018 Aug 31;8(9):87. doi: 10.1038/s41408-018-0123-2.
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