Papadopoulou Aikaterini, Samuels Theophilus Luke, Dassanayake Asitha, Spring Colin, Willers Johann, Uncles David Roy
From the Department of Anesthesia, Worthing Hospital, Worthing, United Kingdom.
A A Case Rep. 2014 Apr 1;2(7):81-2. doi: 10.1097/ACC.0b013e3182a6d853.
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare autoimmune neurological condition. Antibodies targeting glycine receptors (GlyR) have been implicated in PERM. Because GlyR activity is enhanced by inhaled anesthetic drugs at clinically relevant concentrations, there is a theoretical possibility that these drugs may be less effective in the presence of GlyR antibodies. We describe a case of general anesthesia in a patient with PERM and GlyR antibodies. This patient did not demonstrate a clinically significant alteration in the behavioral effects of anesthesia using induction of anesthesia with sevoflurane and maintenance of anesthesia using sevoflurane and nitrous oxide.
进行性脑脊髓炎伴强直和肌阵挛（PERM）是一种罕见的自身免疫性神经系统疾病。靶向甘氨酸受体（GlyR）的抗体与PERM有关。由于吸入麻醉药在临床相关浓度下可增强GlyR活性，因此理论上这些药物在存在GlyR抗体的情况下可能效果较差。我们描述了一例患有PERM和GlyR抗体患者的全身麻醉情况。该患者在使用七氟醚诱导麻醉并使用七氟醚和氧化亚氮维持麻醉的过程中，麻醉行为效应未出现具有临床意义的改变。
