Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Am J Transplant. 2015 Feb;15(2):305-11. doi: 10.1111/ajt.13073.
Over the past several years, the field of transplantation has witnessed significant progress on several fronts; in particular, achievements have been made in devising novel immunosuppressive strategies. An under-explored area that may hold great potential to improve transplantation outcomes is the design of novel strategies to apply specifically to organs to reduce intra-graft inflammation. A growing body of evidence indicates a key role of intra-graft inflammatory cascade in potently instigating the alloimmune response. Indeed, controlling the activation of innate immunity/inflammatory responses has been shown to be a promising strategy to increase the graft acceptance and survival. In this minireview, we provide an overview of emerging targeted strategies, which can be directly applied to grafts to down-regulate intra-graft inflammation prior to transplantation.
在过去的几年中，移植领域在多个方面取得了重大进展；特别是在设计新型免疫抑制策略方面取得了成就。一个尚未得到充分探索的领域，可能具有改善移植结果的巨大潜力，那就是设计专门针对器官的新型策略，以减少移植物内炎症。越来越多的证据表明，移植物内炎症级联在强烈引发同种免疫反应方面起着关键作用。事实上，控制先天免疫/炎症反应的激活已被证明是一种增加移植物接受和存活的有前途的策略。在这篇迷你综述中，我们概述了新兴的靶向策略，这些策略可以在移植前直接应用于移植物，以下调移植物内炎症。
