Baron Anne, Lingueglia Eric
CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France; Université de Nice Sophia Antipolis, 06560 Valbonne, France; LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France.
CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 06560 Valbonne, France; Université de Nice Sophia Antipolis, 06560 Valbonne, France; LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France.
Neuropharmacology. 2015 Jul;94:19-35. doi: 10.1016/j.neuropharm.2015.01.005. Epub 2015 Jan 19.
Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has become a key challenge to study their structure, their molecular and cellular functions and their physiopathological roles. This review provides a summary of the different compounds that directly interact with these channels, either with inhibitory or stimulatory effect, and with high selectivity or poor specificity. They include drugs and endogenous regulators, natural compounds of vegetal origin, and peptides isolated from animal venoms. The in vivo use of some of these pharmacological modulators in animal models and a few small clinical studies in humans have provided substantial data on the physiological and physiopathological roles of ASIC channels. Modulation of these channels will certainly provide new therapeutic opportunities in neurological and psychiatric diseases including pain, stroke, epilepsy, anxiety, depression or traumatic injury, as well as in some non-neurological pathologies. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.
酸敏感离子通道（ASICs）药理学的发展已成为研究其结构、分子和细胞功能以及生理病理作用的关键挑战。本综述总结了与这些通道直接相互作用的不同化合物，这些化合物具有抑制或刺激作用，且具有高选择性或低特异性。它们包括药物和内源性调节剂、植物来源的天然化合物以及从动物毒液中分离出的肽。其中一些药理调节剂在动物模型中的体内应用以及在人类中的一些小型临床研究，为ASIC通道的生理和病理生理作用提供了大量数据。对这些通道的调节肯定会为包括疼痛、中风、癫痫、焦虑、抑郁或创伤性损伤在内的神经和精神疾病以及一些非神经病理学疾病提供新的治疗机会。本文是名为“神经系统中的酸敏感离子通道”特刊的一部分。
