Giniatullin R A, Khazipov R N
Biull Eksp Biol Med. 1989 Dec;108(12):654-7.
The possibility of desensitization (DS) development under the rhythmic activity and during the generation of the single response to acetylcholine was studied in the frog sartorius muscle by voltage-clamp technique. It was revealed, that under conditions promoting DS (hyperpolarization, muscle warming, rise of calcium concentration as well as treatment by the DS--potentiating agent--proadifen) decrease of the postsynaptic membrane sensitivity to the acetylcholine can develop after few multiquantal end-plate currents--and when acetylcholinesterase is inhibited--during the response to a single quantum of acetylcholine.
运用电压钳技术，在青蛙缝匠肌中研究了在节律性活动下以及对乙酰胆碱产生单个反应期间脱敏（DS）发展的可能性。结果表明，在促进DS的条件下（超极化、肌肉升温、钙浓度升高以及用DS增强剂——丙胺太林处理），在少数多量子终板电流之后——以及当乙酰胆碱酯酶被抑制时——在对单个乙酰胆碱量子的反应过程中，突触后膜对乙酰胆碱的敏感性会降低。
