Arena A, Merendino R A, Mastroeni P, Mancuso G, Costa G B, Bonina L
Institute of Medical Microbiology, University of Messina, Italy.
Int J Tissue React. 1989;11(4):169-73.
It is generally agreed that endotoxins from Gram-negative bacteria play a modulatory role on several macrophage functions. The intrinsic activity versus herpes simplex virus type 1 and type 2 of Kupffer cells, peritoneal and alveolar macrophages, harvested from normal and tumour-bearing rats, was evaluated. Moreover, the effects of different intravenous treatments with S. enteritidis endotoxin were investigated. The antiviral activity of peritoneal, alveolar macrophages and Kupffer cells from tumour-bearing rats is definitely impaired but it appears to be positively modulated by in-vivo administration of S. enteritidis lipopolysaccharide (LPS).
一般认为，革兰氏阴性菌产生的内毒素对巨噬细胞的多种功能具有调节作用。我们评估了从正常大鼠和荷瘤大鼠获取的库普弗细胞、腹腔巨噬细胞和肺泡巨噬细胞对1型和2型单纯疱疹病毒的固有活性。此外，还研究了不同剂量肠炎沙门氏菌内毒素静脉注射治疗的效果。荷瘤大鼠的腹腔巨噬细胞、肺泡巨噬细胞和库普弗细胞的抗病毒活性确实受损，但肠炎沙门氏菌脂多糖（LPS）的体内给药似乎对其有正向调节作用。
