Fan Fenxia, Kan Biao
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China,
Virol Sin. 2015 Feb;30(1):19-25. doi: 10.1007/s12250-014-3550-7. Epub 2015 Jan 20.
The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally (inter-strain) and vertically (cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of V. cholerae, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage's role in the evolutionary and epidemiological mechanisms of V. cholerae.
霍乱弧菌的溶原性噬菌体CTXΦ可水平（菌株间）和垂直（细胞增殖）转移霍乱毒素基因。由于其在形态和种类上的多样性、调控机制的复杂性以及感染机制在霍乱弧菌新毒力菌株产生中的重要作用，对溶原性噬菌体CTXΦ的研究备受关注。基于当前研究进展，综述了CTXΦ噬菌体的基因组特征及其排列、宿主依赖性的存活、增殖和传播调控机制，以进一步了解该噬菌体在霍乱弧菌进化和流行病学机制中的作用。
