Tabarin A, Corcuff B, Dauthribes M, San-Galli F, Cochet C, Guerin J, Roger P
Service d'Endocrinologie, Hôpital Saint-André, Bordeaux.
Ann Endocrinol (Paris). 1989;50(6):497-502.
The ACTH and cortisol responses after CRF administration were studied in 21 patients with adrenal failure and compared with those obtained in 15 control subjects. In patients with Addison's disease, cortisol and ACTH responses were respectively abolished or excessive. In patients with secondary adrenal failure, a unique bolus injection of CRF allows the differentiation between pituitary or hypothalamic secretory defect. With regard to previous reports, the usefulness of CRF test in primary and secondary adrenal failure is stressed.
对21例肾上腺功能不全患者给予促肾上腺皮质激素释放因子（CRF）后促肾上腺皮质激素（ACTH）和皮质醇的反应进行了研究，并与15名对照受试者的反应进行了比较。在艾迪生病患者中，皮质醇和ACTH反应分别消失或过度。在继发性肾上腺功能不全患者中，单次注射CRF可区分垂体或下丘脑分泌缺陷。关于既往报道，强调了CRF试验在原发性和继发性肾上腺功能不全中的实用性。
