Hermus A R, Pieters G F, Pesman G J, Smals A G, Benraad T J, Kloppenborg P W
Clin Endocrinol (Oxf). 1985 Jun;22(6):761-9. doi: 10.1111/j.1365-2265.1985.tb00166.x.
The ACTH and cortisol responses to an intravenous bolus injection of 100 micrograms ovine CRF were studied in 19 patients with adrenal failure. In all eight patients with primary adrenal failure, plasma ACTH levels increased from a mean basal level of 1494 +/- 431 (SEM) pg/ml to peak value of 2601 +/- 1220 pg/ml at 10 min. In comparison with healthy subjects absolute ACTH increments after ovine CRF were significantly augmented in the patients with Addison's disease (P* less than 0.001), and the absolute ACTH responses after ovine CRF were positively correlated with the basal plasma ACTH levels. The 11 patients with secondary adrenal insufficiency could be subdivided into two groups: (A) those having little or no ACTH and cortisol response to ovine CRF (five patients) and (B) those having prolonged and pronounced ACTH responses with a biphasic pattern and a delayed second peak (six patients), followed in all patients by a marked cortisol increase. These data demonstrate that the CRF-test can discriminate between hypothalamic and pituitary causes of secondary adrenal failure.
对19例肾上腺功能不全患者静脉推注100微克羊促肾上腺皮质激素释放因子（ovine CRF）后促肾上腺皮质激素（ACTH）和皮质醇的反应进行了研究。在所有8例原发性肾上腺功能不全患者中，血浆ACTH水平从平均基础水平1494±431（标准误）皮克/毫升在10分钟时升至峰值2601±1220皮克/毫升。与健康受试者相比，艾迪生病患者静脉注射羊CRF后ACTH的绝对增量显著增加（P*<0.001），且静脉注射羊CRF后ACTH的绝对反应与基础血浆ACTH水平呈正相关。11例继发性肾上腺功能不全患者可分为两组：（A）对羊CRF几乎没有或没有ACTH和皮质醇反应的患者（5例）；（B）ACTH反应延长且明显、呈双相模式且第二个峰值延迟的患者（6例），所有患者随后皮质醇均显著增加。这些数据表明，CRF试验可区分继发性肾上腺功能不全的下丘脑和垂体病因。
