Fröhlich Eckhart, Muller Reinhold, Cui Xin-Wu, Schreiber-Dietrich Dagmar, Dietrich Christoph F
Department of Internal Medicine I, Karl-Olga-Krankenhaus Stuttgart, Academic Teaching Hospital of the University of Ulm, Germany (E.F.); Tropical Health Solutions Pty, Ltd, and Anton-Breinl Center, James Cook University, Townsville City, Queensland, Australia (R.M.); Sino-German Research Center of Ultrasound in Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, and Department of Internal Medicine II, Caritas-Krankenhaus Bad Mergentheim, Academic Teaching Hospital of the University of Würzburg, Bad Mergentheim, Germany (X.-W.C., D.S.-D., C.F.D.).
J Ultrasound Med. 2015 Feb;34(2):179-96. doi: 10.7863/ultra.34.2.179.
Dynamic contrast-enhanced ultrasound (US) imaging, a technique that uses microbubble contrast agents with diagnostic US, has recently been technically summarized and reviewed by a European Federation of Societies for Ultrasound in Medicine and Biology position paper. However, the practical applications of this imaging technique were not included. This article reviews and discusses the published literature on the clinical use of dynamic contrast-enhanced US. This review finds that dynamic contrast-enhanced US imaging is the most sensitive cross-sectional real-time method for measuring the perfusion of parenchymatous organs noninvasively. It can measure parenchymal perfusion and therefore can differentiate between benign and malignant tumors. The most important routine clinical role of dynamic contrast-enhanced US is the prediction of tumor responses to chemotherapy within a very short time, shorter than using Response Evaluation Criteria in Solid Tumors criteria. Other applications found include quantifying the hepatic transit time, diabetic kidneys, transplant grafts, and Crohn disease. In addition, the problems involved in using dynamic contrast-enhanced US are discussed.
动态对比增强超声（US）成像技术，即一种将微泡造影剂与诊断性超声相结合的技术，近期已由欧洲医学与生物学超声学会联合会的一篇立场文件进行了技术总结与综述。然而，该成像技术的实际应用并未涵盖其中。本文对已发表的关于动态对比增强超声临床应用的文献进行综述与讨论。本综述发现，动态对比增强超声成像是非侵入性测量实质器官灌注的最敏感的横断面实时方法。它能够测量实质灌注，因此可区分良性和恶性肿瘤。动态对比增强超声在常规临床中最重要的作用是在极短时间内预测肿瘤对化疗的反应，这比使用实体瘤疗效评价标准的时间更短。发现的其他应用包括量化肝转运时间、糖尿病肾病、移植移植物以及克罗恩病。此外，还讨论了使用动态对比增强超声所涉及的问题。
