Nikdoust Farahnaz, Tabatabaei Seyed Abdolhosein, Shafiee Akbar, Mostafavi Atoosa, Mohamadi Maryam, Mohammadi Sareh
Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IR Iran.
Int Cardiovasc Res J. 2014 Dec;8(4):148-51. Epub 2014 Dec 1.
Right Ventricular (RV) dysfunction has been introduced as a predictor of mortality in acute myocardial infarction.
This study aimed to investigate the effect of right coronary revascularization on systolic and diastolic RV dysfunction.
This study was conducted on unstable angina patients who were candidate for elective Percutaneous Revascularization Intervention (PCI) on the right coronary artery. The participants were initially evaluated by transthoracic echocardiography and tissue Doppler imaging prior to PCI and the RV function parameters were assessed. Echocardiography was repeated two months after PCI and the results were compared with baseline. Paired t-test was used to compare the pre- and post-procedural measurements. Besides, Pearson's correlation was used to find out the linear association between the RV function parameters and Left Ventricular Ejection Fraction (LVEF). P value < 0.05 was considered as statistically significant.
This study was conducted on 30 patients (mean age = 60.00 ± 8.44 years; 24 [80%] males). In the pre-procedural echocardiography, 15 patients (50%) had normal RV function, 14 patients (46.7%) had grade-1 RV dysfunction, and only 1 patient (3.3%) had grade-2 RV dysfunction. Following PCI, however, all the patients had normal systolic and diastolic RV functions. Comparison of echocardiographic RV function parameters showed an improvement in both systolic and diastolic functional parameters of the RV. Nonetheless, no significant correlation was observed between these parameters and Left Ventricular (LV) function.
A significant improvement was found in RV function, but not LV function, after right coronary PCI. Revascularization of the right coronary artery may be beneficial for the patients who suffer from RV failure due to ischemia.
右心室功能障碍已被视为急性心肌梗死死亡率的预测指标。
本研究旨在探讨右冠状动脉血运重建对右心室收缩和舒张功能障碍的影响。
本研究针对不稳定型心绞痛患者开展，这些患者均为择期经皮冠状动脉介入治疗（PCI）右冠状动脉的候选对象。参与者在PCI术前首先接受经胸超声心动图和组织多普勒成像评估，并对右心室功能参数进行评估。PCI术后两个月重复进行超声心动图检查，并将结果与基线进行比较。采用配对t检验比较手术前后的测量值。此外，使用Pearson相关性分析来找出右心室功能参数与左心室射血分数（LVEF）之间的线性关联。P值<0.05被认为具有统计学意义。
本研究共纳入30例患者（平均年龄 = 60.00 ± 8.44岁；24例[80%]为男性）。在术前超声心动图检查中，15例患者（50%）右心室功能正常，14例患者（46.7%）存在1级右心室功能障碍，仅有1例患者（3.3%）存在2级右心室功能障碍。然而，PCI术后所有患者的右心室收缩和舒张功能均恢复正常。超声心动图右心室功能参数比较显示，右心室收缩和舒张功能参数均有所改善。尽管如此，这些参数与左心室功能之间未观察到显著相关性。
右冠状动脉PCI术后右心室功能有显著改善，但左心室功能未改善。右冠状动脉血运重建可能对因缺血导致右心室衰竭的患者有益。
