Verrotti Alberto, Milioni Maddalena, Zaccara Gaetano
Department of Pediatrics, University of Perugia, Piazza Università 1, 06123, Perugia, Italy.
Expert Rev Neurother. 2015 Feb;15(2):127-33. doi: 10.1586/14737175.2015.1003043.
Benzodiazepines represent the first choice treatment of acute repetitive seizures, and diazepam is one of the main drugs administered to epileptic patients in the prehospital setting. Currently, Diazepam rectal gel is the only approved therapy for the outpatient management of seizures, but there is a growing need for alternative medications for terminating seizures that may be not only safe and effective but also socially acceptable. According to this, the autoinjector device appears to be a promising tool for the treatment of acute repetitive seizures. Recent studies comparing diazepam autoinjector (AI) with placebo suggest that diazepam AI could be a safe and effective option to treat acute repetitive seizures when administered by trained caregivers in outpatient settings. However, additional studies comparing diazepam AI with a standard treatment are necessary to define possible added benefits of this technique.
苯二氮䓬类药物是急性重复性癫痫发作的首选治疗药物，地西泮是院前环境中给予癫痫患者的主要药物之一。目前，地西泮直肠凝胶是唯一获批用于门诊癫痫管理的疗法，但越来越需要有替代药物来终止癫痫发作，这些药物不仅要安全有效，还要为社会所接受。据此，自动注射器装置似乎是治疗急性重复性癫痫发作的一种有前景的工具。最近比较地西泮自动注射器（AI）与安慰剂的研究表明，在门诊环境中由经过培训的护理人员给药时，地西泮AI可能是治疗急性重复性癫痫发作的一种安全有效的选择。然而，需要进行更多比较地西泮AI与标准治疗的研究，以确定该技术可能带来的额外益处。
