Zambon João Paulo, Almeida Fernando G, Conceição Raquel Dilguerian O, Tabone Viviane Arevalo, Kashiwagi Nea Miwa, Ross Christina L, Carvalho José Antônio Maluf de
Department of Urology, Universidade Federal de Sao Paulo, SP, Brazil; Hospital Israelita Albert Einstein, SP, Brazil and Wake Forest University, Winston-Salem, North Carolina, USA.
Department of Urology, Universidade Federal de Sao Paulo, SP, Brazil.
Int Braz J Urol. 2014 Nov-Dec;40(6):745-52. doi: 10.1590/S1677-5538.IBJU.2014.06.05.
To evaluate the PSA in a large population of Brazilian men undergone to check up, and correlate the PSA cutoffs with prostate size and urinary symptoms.
This is a cross sectional study performed with men between 40 and 70 years undergone to check-up. All men were undergone to urological evaluation, digital rectal examination, prostate-specific antigen, and ultrasonography The exclusion criteria were men who used testosterone in the last six months, or who were using 5 alpha-reductase inhibitors.
A total of 5015 men with an average age of 49.0 years completed the study. Most men were white and asymptomatic. The PSA in the three different aging groups were 0.9 ± 0.7 ng/dL for men between 40 and 50; 1.2 ± 0.5 ng/dL for men between 50 and 60; and 1.7 ± 1.5 ng/dL for men greater than 60 years (p=0.001). A total of 192 men had PSA between 2.5 and 4 ng/ml. From these men 130 were undergone to prostate biopsy. The predictive positive value of biopsy was 25% (32/130). In the same way, 100 patients had PSA > 4 ng/mL. From these men, 80 were undergone to prostate biopsy. In this group, the predictive positive value of biopsy was 40% (32/100). The Gleason score was 6 in 19 men (60%), 7 in 10 men (31%) and 8 in 3 men (9%).
The PSA level of Brazilian men undergone to check up was low. There was a positive correlation with aging, IPSS and prostate size.
评估大量接受体检的巴西男性的前列腺特异性抗原（PSA），并将PSA临界值与前列腺大小和泌尿系统症状相关联。
这是一项对40至70岁接受体检男性进行的横断面研究。所有男性均接受了泌尿外科评估、直肠指检、前列腺特异性抗原检测及超声检查。排除标准为过去六个月内使用过睾酮或正在使用5α还原酶抑制剂的男性。
共有5015名平均年龄为49.0岁的男性完成了研究。大多数男性为白人且无症状。40至50岁男性的PSA为0.9±0.7 ng/dL；50至60岁男性为1.2±0.5 ng/dL；60岁以上男性为1.7±1.5 ng/dL（p=0.001）。共有192名男性的PSA在2.5至4 ng/ml之间。其中130人接受了前列腺活检。活检的预测阳性值为25%（32/130）。同样，100名患者的PSA>4 ng/mL。其中80人接受了前列腺活检。该组活检的预测阳性值为40%（32/100）。Gleason评分6分的有19名男性（60%），7分的有10名男性（31%），8分的有3名男性（9%）。
接受体检的巴西男性的PSA水平较低。其与年龄增长、国际前列腺症状评分（IPSS）和前列腺大小呈正相关。
