Matura Lea Ann, Ventetuolo Corey E, Palevsky Harold I, Lederer David J, Horn Evelyn M, Mathai Stephen C, Pinder Diane, Archer-Chicko Christine, Bagiella Emilia, Roberts Kari E, Tracy Russell P, Hassoun Paul M, Girgis Reda E, Kawut Steven M
1 University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania.
Ann Am Thorac Soc. 2015 Mar;12(3):370-5. doi: 10.1513/AnnalsATS.201410-463OC.
Inflammation is associated with symptoms in many chronic illnesses; however, this link has not been established in pulmonary arterial hypertension.
The objective of this study was to investigate the association between inflammatory markers and quality of life-related symptoms in patients with pulmonary arterial hypertension. We hypothesized that higher circulating IL-6 and tumor necrosis factor-α levels would be associated with worse quality of life-related symptoms.
We performed a secondary analysis using baseline and 3-month assessments of 62 subjects in a clinical trial of aspirin and simvastatin to determine the association between plasma IL-6 and tumor necrosis factor-α levels and the Medical Outcomes Study Short Form-36 subscales (pain, vitality, mental health).
The mean age was 49.7±13.4 years; 87% were female. Higher IL-6 levels were significantly associated with lower Medical Outcomes Study Short Form-36 subscale scores, indicating worse bodily pain, vitality, and mental health (all P<0.01). Higher tumor necrosis factor-α levels were significantly associated with increased bodily pain, but better mental health scores.
IL-6 and tumor necrosis factor-α levels are associated with certain quality of life domains in patients with pulmonary arterial hypertension. Clinical trial registered with www.clinicaltrials.gov (NCT00384865).
炎症与许多慢性疾病的症状相关；然而，这种联系在肺动脉高压中尚未得到证实。
本研究的目的是调查肺动脉高压患者炎症标志物与生活质量相关症状之间的关联。我们假设循环中白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平升高与生活质量相关症状恶化有关。
我们在一项阿司匹林和辛伐他汀的临床试验中，对62名受试者的基线和3个月评估进行了二次分析，以确定血浆IL-6和TNF-α水平与医学结局研究简明健康调查36项量表（疼痛、活力、心理健康）之间的关联。
平均年龄为49.7±13.4岁；87%为女性。较高的IL-6水平与较低的医学结局研究简明健康调查36项量表评分显著相关，表明身体疼痛、活力和心理健康状况较差（所有P<0.01）。较高的TNF-α水平与身体疼痛增加显著相关，但心理健康评分较好。
IL-6和TNF-α水平与肺动脉高压患者的某些生活质量领域相关。临床试验已在www.clinicaltrials.gov注册（NCT00384865）。
