[(14)C] -甾体中间体的合成：非稳定型霍纳 - 沃兹沃思 - 埃蒙斯烯烃化方法的应用
Synthesis of a [(14) C]-steroid intermediate: an application of a nonstabilized Horner-Wadsworth-Emmons olefination approach.
作者信息
Rivera Nelo R, Ren Sumei, Hesk David
机构信息
Department of Process Chemistry, Merck Research Laboratories, 126 E. Lincoln Ave., PO Box 2000, Rahway, NJ, 07065, USA.
出版信息
J Labelled Comp Radiopharm. 2015 Jan;58(1):20-2. doi: 10.1002/jlcr.3257.
PMID:25616231
Abstract
Radiolabeled steroid derivative 1 was successfully prepared using a Horner-Wadsworth-Emmons approach: a [(14) C]-label was efficiently incorporated into the C-18 position of the molecule. Previously published procedures employing other olefination methods are either not applicable due to unavailability of [(14) C]-precursors or suffer from poor reactivity.
摘要
放射性标记的类固醇衍生物1通过霍纳-沃兹沃思-埃蒙斯方法成功制备：一个[(14)C]标记被有效地引入到分子的C-18位。以前发表的采用其他烯烃化方法的程序，要么由于[(14)C]前体不可用而不适用，要么反应性较差。
相似文献
1
Synthesis of a [(14) C]-steroid intermediate: an application of a nonstabilized Horner-Wadsworth-Emmons olefination approach.[(14)C] -甾体中间体的合成：非稳定型霍纳 - 沃兹沃思 - 埃蒙斯烯烃化方法的应用
J Labelled Comp Radiopharm. 2015 Jan;58(1):20-2. doi: 10.1002/jlcr.3257.
2
Synthesis of unsaturated organotrifluoroborates via Wittig and Horner-Wadsworth-Emmons olefination.通过维蒂希反应和霍纳-沃兹沃思-埃蒙斯烯化反应合成不饱和有机三氟硼酸盐。
J Org Chem. 2006 Aug 4;71(16):6135-40. doi: 10.1021/jo060863w.
3
Organocatalytic sequential alpha-amination-Horner-Wadsworth-Emmons olefination of aldehydes: enantioselective synthesis of gamma-amino-alpha,beta-unsaturated esters.醛的有机催化顺序α-胺化-霍纳尔-沃兹沃思-埃蒙斯烯烃化反应：γ-氨基-α,β-不饱和酯的对映选择性合成
Org Lett. 2007 Mar 15;9(6):1001-4. doi: 10.1021/ol063012j. Epub 2007 Feb 13.
4
Enantioselective synthesis of syn/anti-1,3-amino alcohols via proline-catalyzed sequential alpha-aminoxylation/alpha-amination and Horner-Wadsworth-Emmons olefination of aldehydes.通过脯氨酸催化的连续 α-氨氧化/α-氨基化和醛的 Horner-Wadsworth-Emmons 烯烃化反应对映选择性合成 syn/anti-1,3-氨基醇。
Org Lett. 2010 Jun 18;12(12):2762-5. doi: 10.1021/ol100856u.
5
Studies on the synthesis of apoptolidin: synthesis of a C1-C27 fragment of apoptolidin D.凋亡肽 D 的 C1-C27 片段的合成：凋亡肽的合成研究。
J Org Chem. 2011 Oct 7;76(19):7834-41. doi: 10.1021/jo200934w. Epub 2011 Aug 26.
6
Synthesis of the sulfonate analogue of seminolipid via Horner-Wadsworth-Emmons olefination.通过霍纳-瓦兹沃思-埃蒙斯（Horner-Wadsworth-Emmons）烯烃化反应合成半脂素的磺酸盐类似物。
J Org Chem. 2010 Aug 6;75(15):5363-6. doi: 10.1021/jo1008788.
7
Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation.通过串联 Horner-Wadsworth-Emmons 烯丙基化/环化反应合成功能化的 4H-喹啉-4-酮。
Org Biomol Chem. 2013 May 28;11(20):3337-40. doi: 10.1039/c3ob40578h.
8
Olefination reactions of phosphorus-stabilized carbon nucleophiles.磷稳定碳亲核试剂的烯化反应。
Top Curr Chem. 2012;327:197-238. doi: 10.1007/128_2012_314.
9
Route to α-Aryl Phosphonoacetates: Useful Synthetic Precursors in the Horner-Wadsworth-Emmons Olefination.通往α-芳基膦酰基乙酸酯的路线：霍纳-沃兹沃思-埃蒙斯烯烃化反应中有用的合成前体。
J Org Chem. 2015 Oct 16;80(20):10288-93. doi: 10.1021/acs.joc.5b01887. Epub 2015 Oct 3.
10
Iterative approach to enantiopure syn/anti-1,3-polyols via proline-catalyzed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehydes.通过脯氨酸催化醛的顺序α-氨基氧基化反应和霍纳-沃兹沃思-埃蒙斯烯烃化反应制备对映体纯的顺式/反式-1,3-多元醇的迭代方法。
Org Lett. 2009 Jun 18;11(12):2611-4. doi: 10.1021/ol900868v.
Zotero 插件