通过串联 Horner-Wadsworth-Emmons 烯丙基化/环化反应合成功能化的 4H-喹啉-4-酮。
Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation.
机构信息
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Glasgow, UK.
出版信息
Org Biomol Chem. 2013 May 28;11(20):3337-40. doi: 10.1039/c3ob40578h.
PMID:23558690
Abstract
4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.
摘要
4H-喹啉-4-酮是一类具有独特价值的杂环化合物，具有有价值的物理化学性质，并且正在成为一系列生物靶标的关键药效团。开发了一种串联的霍纳-沃兹沃思-埃蒙斯（Horner-Wadsworth-Emmons）烯烃化/环化方法，可方便地获得带有各种功能基团的取代的 4H-喹啉-4-酮。
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