Hue L
Bull Mem Acad R Med Belg. 1989;144(11):570-7; discussion 578-9.
Tumour and proliferative cells maintain a high glycolytic rate even under aerobic conditions. The discovery of fructose-2,6-bisphosphate, a potent stimulator of glycolysis, has prompted a re-investigation of this phenomenon. Rat hepatoma cells and fibroblasts stimulated by mitogens or transformed by the Rous sarcoma virus, were used as models. The results indicate that the stimulation of glycolysis induced by these agents can be explained by an increase in the concentration of fructose-2,6-bisphosphate and in the activity of the enzyme synthesizing it.
肿瘤细胞和增殖细胞即使在有氧条件下也维持着较高的糖酵解速率。果糖-2,6-二磷酸是一种有效的糖酵解刺激剂，这一发现促使人们对这一现象进行重新研究。以受有丝分裂原刺激或被劳氏肉瘤病毒转化的大鼠肝癌细胞和成纤维细胞作为模型。结果表明，这些因子所诱导的糖酵解刺激作用可以通过果糖-2,6-二磷酸浓度的增加及其合成酶活性的增加来解释。
