Lee Young-A, Goto Yukiori
Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan, South Korea.
Neurosci Bull. 2015 Apr;31(2):164-74. doi: 10.1007/s12264-014-1499-z. Epub 2015 Jan 23.
In this article, we propose the hypothesis that the prefrontal cortex (PFC) acquired neotenic development as a consequence of mesocortical dopamine (DA) innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model.
在本文中，我们提出这样一个假说：前额叶皮层（PFC）由于中脑皮层多巴胺（DA）神经支配而获得了幼态发育，这反过来又推动了前额叶皮层演变成一个复杂的功能系统。因此，从进化的角度来看，与慢性应激等不利状况相关的前额叶皮层中多巴胺信号的减少可能被视为一种环境适应策略。精神疾病如精神分裂症和注意力缺陷多动障碍也可能被理解为环境适应或人类进化过程中出现的此类过程的副产品。为了研究前额叶皮层中多巴胺信号的进化观点，像狗这样的家畜可能是一个有用的模型。
