CXCL13/CXCR5/FAK是间充质干细胞迁移和分化的关键调节因子吗？

Are CXCL13/CXCR5/FAK critical regulators of MSCs migration and differentiation?

作者信息

Zhang Yan, Ma Chunhui, Yu Yinxian, Liu Man, Yi Chengqing

机构信息

Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China; The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China.

Department of Orthopedic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.

出版信息

Med Hypotheses. 2015 Mar;84(3):213-5. doi: 10.1016/j.mehy.2014.12.025. Epub 2015 Jan 9.

DOI:10.1016/j.mehy.2014.12.025

PMID:25617044

Abstract

Osteonecrosis of the femoral head is a common and challenging disease worldwide. The traditional treatments, such as core decompression procedure and joint replacement, are not satisfactory due to the limited outcome, repetitive surgery and cost. In recent years, autologous mesenchymal stem cells (MSCs) implantation into the femoral head has emerged as a promising method. The homing and differentiation of MSCs is determined by chemokines and their receptors, specific signals present in the micro-environment of the damaged tissue. CXCL13/CXCR5, highly expressed in the osteoblast and MSCs, are tissue specific and selectively migrate MSCs, thereafter triggering phosphorylation of focal adhesionkinase through mitogen-activated protein kinase pathway. Considering these characteristics, we hypothesize that CXCL13/CXCR5/FAK are critical signals in the trafficking and differentiation of MSCs.

摘要

股骨头坏死是一种在全球范围内常见且具有挑战性的疾病。诸如髓芯减压术和关节置换等传统治疗方法，由于疗效有限、需要重复手术以及费用问题，效果并不理想。近年来，将自体间充质干细胞（MSCs）植入股骨头已成为一种有前景的方法。MSCs的归巢和分化由趋化因子及其受体决定，这些是受损组织微环境中存在的特定信号。CXCL13/CXCR5在成骨细胞和MSCs中高表达，具有组织特异性，可选择性地迁移MSCs，进而通过丝裂原活化蛋白激酶途径触发粘着斑激酶的磷酸化。考虑到这些特性，我们推测CXCL13/CXCR5/FAK是MSCs迁移和分化中的关键信号。