Mo Andrew, Brat Gabriel, Spolverato Gaya, Pawlik Timothy M
Department of Surgery, Johns Hopkins Hospital, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
J Gastrointest Surg. 2015 Apr;19(4):792-4. doi: 10.1007/s11605-015-2750-2. Epub 2015 Jan 24.
Intraductal papillary mucinous neoplasms (IPMNs) are rare, mucin-producing, predominantly noninvasive tumors arising from epithelial cells. Most IPMNs arise from the pancreas. There exists a subset of IPMN of the biliary tract (BT-IPMN). IPMNs regardless of origin produce large amounts of mucin relative to scant amounts of epithelial cells, leading to mass effect disturbances in bile flow. Affected bile ducts exhibit marked dilatation. The majority of IPMN patients present with a non-malignant neoplasm. Because of potential for transformation, surgery is the treatment of choice. Bronchobiliary fistulas can present as congenital defects, following thoracoabodominal trauma, or as rare complications of diseases of the biliary tract such as BT-IPMN. There are no reported cases in the literature of bronchobiliary fistula associated with BT-IPMN, but there is a clear theoretical risk.
导管内乳头状黏液性肿瘤（IPMNs）是一种罕见的、产生黏液的肿瘤，主要由上皮细胞发生，多为非侵袭性。大多数IPMN起源于胰腺。存在一部分胆管（BT-IPMN）的IPMN。无论起源如何，IPMN相对于少量上皮细胞会产生大量黏液，导致胆汁流动的占位效应紊乱。受影响的胆管表现出明显扩张。大多数IPMN患者表现为非恶性肿瘤。由于存在恶变的可能性，手术是首选治疗方法。支气管胆管瘘可表现为先天性缺陷、胸腹部创伤后出现，或作为胆管疾病（如BT-IPMN）的罕见并发症出现。文献中没有关于与BT-IPMN相关的支气管胆管瘘的报道病例，但存在明确的理论风险。
