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Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunity.

作者信息

Smith Ryan C, Jacobs-Lorena Marcelo

机构信息

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205

出版信息

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1250-1. doi: 10.1073/pnas.1424227112. Epub 2015 Jan 23.

Abstract
摘要

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本文引用的文献

1
Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells.
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1273-80. doi: 10.1073/pnas.1423586112. Epub 2014 Dec 31.
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The Plasmodium bottleneck: malaria parasite losses in the mosquito vector.
Mem Inst Oswaldo Cruz. 2014 Aug;109(5):644-61. doi: 10.1590/0074-0276130597.
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The JNK pathway is a key mediator of Anopheles gambiae antiplasmodial immunity.
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The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system.
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Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparum.
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Inducible peroxidases mediate nitration of anopheles midgut cells undergoing apoptosis in response to Plasmodium invasion.
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