Reis Sandra Aparecida dos, Conceição Lisiane Lopes da, Rosa Damiana Diniz, Dias Manoela Maciel dos Santos, Peluzio Maria do Carmo Gouveia
Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil..
Nutr Hosp. 2014 Jan 1;31(2):528-34. doi: 10.3305/nh.2015.31.2.7706.
The consumption of prebiotics has been associated with improvement in the lipid profile. Thus, this review aims to describe the main mechanisms by which inulin-type fructans improve the lipid profile and thereby reduce the cardiovascular risk.
Inulin-type fructans have been demonstrated to improve the lipid profile through a number of mechanisms. These mechanisms include: decrease in gene expression of hepatic enzymes responsible for de novo synthesis of lipids; increase of muscle lipoprotein lipase enzyme activity, enhancing the production of short-chain fatty acids; altered production of polyamines which increases the production of satiogenic peptide; altered blood glucose and insulinemia; increase of fecal excretion of bile salts and cholesterol and increase of the Bifidobacterium population.
The consumption of inulin-type fructans enhances lipid profile. Generally, the mechanisms vary according to the physiologic state of the individual and the type of diet to which the inulin-type fructans are added. Thus, inulin may be used for the prevention and/or treatment of cardiovascular diseases.
益生元的摄入与脂质谱改善相关。因此，本综述旨在描述菊粉型果聚糖改善脂质谱从而降低心血管风险的主要机制。
已证实菊粉型果聚糖可通过多种机制改善脂质谱。这些机制包括：负责脂质从头合成的肝酶基因表达降低；肌肉脂蛋白脂肪酶活性增加，增强短链脂肪酸的产生；多胺产生改变，增加饱腹感肽的产生；血糖和胰岛素血症改变；胆汁盐和胆固醇的粪便排泄增加以及双歧杆菌数量增加。
食用菊粉型果聚糖可改善脂质谱。一般来说，这些机制因个体的生理状态以及添加菊粉型果聚糖的饮食类型而异。因此，菊粉可用于预防和/或治疗心血管疾病。
