Marin Flávia Andréia, Rasera Junior Irineu, Leite Celso Vieira De Souza, Oliveira Maria Rita Marques de
Programa de Pós-Graduação em Alimentos e Nutrição - Ciências Nutricionais, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas (UNESP-FcFar), Araraquara-SP.
Centro de Gastroenterologia e Cirurgia da Obesidade - Clínica Bariátrica, Hospital Fornecedores de Cana, Piracicaba-SP. Faculdade de Medicina da Universidade Estadual Paulista (FMUNESP), Botucatu-SP..
Nutr Hosp. 2014 Oct 16;31(2):666-71. doi: 10.3305/nh.2015.31.2.7629.
In addition to its important role as marker of iron stores, serum ferritin is a marker of systemic inflammation, and obesity has been associated with chronic inflammation.
To verify, six months after surgery, the effect of bariatric surgery on the serum ferritin of women who were hypertensive, diabetic, or comorbidity free before surgery.
This retrospective study included 200 women aged 20 to 45 years, with a body mass index (BMI) equal to or greater than 35 kg/m2, submitted to Roux-en-Y gastric bypass (RYGB). Seventy of these women were hypertensive, forty had type 2 diabetes (T2D), and ninety were comorbidity free (CF). They were assessed before and six months after surgery. Anthropometric, laboratory (serum ferritin and hemoglobin), and comorbidity- related data were collected from their medical records.
Before surgery, women with comorbidities were older, the hypertensives had higher BMI, and the diabetics had higher serum ferritin levels than the CF women. The study comorbidities had resolved in 68% of the hypertensive women and 86% of the diabetic women six months after RYGB. Also at this time, the serum ferritin of hypertensive women decreased from 110.1±86.3 to 88.7±80.5 ng/dL and of diabetic women, from 164.8±133.4 to 101.2±97.7 ng/dL (p0.05).
High ferritin in premenopausal obese women was associated with the main obesity-related comorbidities, and these comorbidities determined the reduction of serum ferritin after bariatric surgery.
血清铁蛋白除了作为铁储备的重要标志物外，还是全身炎症的标志物，而肥胖与慢性炎症有关。
在手术后六个月，验证减肥手术对术前患有高血压、糖尿病或无合并症的女性血清铁蛋白的影响。
这项回顾性研究纳入了200名年龄在20至45岁之间、体重指数（BMI）等于或大于35kg/m²的女性，她们接受了Roux-en-Y胃旁路术（RYGB）。其中70名女性患有高血压，40名患有2型糖尿病（T2D），90名无合并症（CF）。在手术前和手术后六个月对她们进行评估。从她们的病历中收集人体测量学、实验室（血清铁蛋白和血红蛋白）以及与合并症相关的数据。
手术前，患有合并症的女性年龄较大，高血压患者BMI较高，糖尿病患者血清铁蛋白水平高于无合并症女性。RYGB术后六个月时，68%的高血压女性和86%的糖尿病女性合并症得到缓解。此时，高血压女性的血清铁蛋白从110.1±86.3降至88.7±80.5 ng/dL，糖尿病女性从164.8±133.4降至101.2±97.7 ng/dL（p<0.05）。
绝经前肥胖女性中铁蛋白水平升高与主要的肥胖相关合并症有关，这些合并症决定了减肥手术后血清铁蛋白的降低。
