Seidel Maria, King Joseph A, Ritschel Franziska, Döpmann Johanna, Bühren Katharina, Seitz Jochen, Roessner Veit, Westphal Sabine, Egberts Karin, Burghardt Roland, Wewetzer Christoph, Fleischhaker Christian, Hebebrand Johannes, Herpertz-Dahlmann Beate, Ehrlich Stefan
Department of Child and Adolescent Psychiatry, Eating Disorder Services and Research Center, Technische Universität Dresden, Faculty of Medicine, University Hospital C. G. Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Psychoneuroendocrinology. 2015 Mar;53:127-35. doi: 10.1016/j.psyneuen.2014.12.010. Epub 2014 Dec 31.
Visfatin is a recently described protein that is thought to regulate the process of adipocyte differentiation. Findings suggest that visfatin may be actively involved in the control of weight regulatory networks. However, to what extent and which role it plays in eating disorders is still poorly understood, as mixed results have been reported. The aim of the current study was to investigate serum visfatin concentrations on a cross sectional sample between acute anorexia nervosa patients (n=44), weight recovered patients (n=13) and healthy controls (n=46) and a longitudinal sample of acute patients (n=57) during weight recovery at three different time-points. Results did not show significant differences in visfatin between the three groups; however, acute patients showed a higher visfatin/BMI-SDS ratio than controls and recovered patients. Longitudinal results revealed an increase of visfatin levels during therapy. Our results suggest that high ratios of visfatin/BMI-SDS could be a state marker in acute anorexia nervosa, displaying a compensatory mechanism of the individual to maintain normal visfatin levels under malnourished conditions.
内脂素是一种最近被描述的蛋白质，被认为可调节脂肪细胞分化过程。研究结果表明，内脂素可能积极参与体重调节网络的控制。然而，由于报告的结果不一，其在饮食失调中所起的作用程度仍知之甚少。本研究的目的是在急性神经性厌食症患者（n = 44）、体重恢复患者（n = 13）和健康对照者（n = 46）的横断面样本以及急性患者（n = 57）在体重恢复期间三个不同时间点的纵向样本中，研究血清内脂素浓度。结果显示三组之间内脂素无显著差异；然而，急性患者的内脂素/体重指数标准差（BMI-SDS）比值高于对照组和康复患者。纵向结果显示治疗期间内脂素水平升高。我们的结果表明，高内脂素/BMI-SDS比值可能是急性神经性厌食症的一种状态标志物，显示了个体在营养不良条件下维持正常内脂素水平的一种代偿机制。
