Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic.
Physiol Res. 2009;58(6):903-907. doi: 10.33549/physiolres.931680. Epub 2008 Dec 17.
Visfatin is an adipose tissue-derived hormone shown to correlate with visceral fat mass in patients with obesity. Its possible role in patients with different types of eating disorders is unknown. We measured fasting serum levels of visfatin and leptin and surrogate measures of insulin sensitivity in 10 untreated patients with anorexia nervosa (AN), 10 untreated patients with bulimia nervosa (BN) and 20 age-matched healthy women (C) to study the possible role of visfatin in these disorders. Patients with AN had severely decreased body mass index (BMI) and body fat content. BMI of BN group did not significantly differ from that of C group, whereas body fat content of BN group was significantly lower compared to C and higher compared to AN group, respectively. Serum glucose levels did not significantly differ among the groups studied, whereas serum insulin and leptin levels and HOMA index were significantly decreased in AN group relative to both C and BN group. In contrast, serum visfatin levels in both patients with AN and BN did not differ from those of C group. We conclude that circulating visfatin levels are not affected by the presence of chronic malnutrition in AN or binge/purge eating behavior in BN.
内脂素是一种脂肪组织来源的激素，与肥胖患者的内脏脂肪量相关。其在不同类型饮食失调症患者中的可能作用尚不清楚。我们测定了 10 例未经治疗的神经性厌食症（AN）患者、10 例未经治疗的神经性贪食症（BN）患者和 20 名年龄匹配的健康女性（C）的空腹血清内脂素和瘦素水平以及胰岛素敏感性替代指标，以研究内脂素在这些疾病中的可能作用。AN 患者的体重指数（BMI）和体脂含量严重降低。BN 组的 BMI 与 C 组无显著差异，而 BN 组的体脂含量明显低于 C 组，高于 AN 组。研究组的血清葡萄糖水平无显著差异，而 AN 组的血清胰岛素、瘦素水平和 HOMA 指数与 C 组和 BN 组相比均显著降低。相反，AN 和 BN 患者的血清内脂素水平与 C 组无差异。我们的结论是，循环内脂素水平不受 AN 中的慢性营养不良或 BN 中的暴食/清除行为的影响。
