Xu Xing-Yu, Sun Peng, Guo De-An, Liu Xuan, Liu Jun-Hua, Hu Li-Hong
Shanghai Research Center for the Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China.
Shanghai Research Center for the Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China.
Fitoterapia. 2015 Mar;101:218-23. doi: 10.1016/j.fitote.2015.01.011. Epub 2015 Jan 21.
Two new sesquiterpene lactone dimers, neojaponicone B (1) and inulanolide E (2) along with five known sesquiterpene lactone dimers (3-7, resp.) were isolated from the aerial parts of Inula japonica Thunb. The chemical structures of 1 and 2 were elucidated by detailed spectroscopic analysis. The relative configuration of 2 was confirmed by biomimetic transformation from the known sesquiterpene lactone dimer inulanolide A (3). The cytotoxicities of the isolated sesquiterpene lactone dimers were evaluated against 6T-CEM and Jurkat cell lines. All compounds showed potent cytotoxicities with IC50 value of 2.2-5.9μm.
从旋覆花的地上部分分离得到两个新的倍半萜内酯二聚体，新日本蜂斗菜内酯B（1）和旋覆花内酯E（2），以及五个已知的倍半萜内酯二聚体（分别为3 - 7）。通过详细的光谱分析阐明了1和2的化学结构。通过从已知的倍半萜内酯二聚体旋覆花内酯A（3）进行仿生转化，确定了2的相对构型。评估了分离得到的倍半萜内酯二聚体对6T - CEM和Jurkat细胞系的细胞毒性。所有化合物均表现出较强的细胞毒性，IC50值为2.2 - 5.9μm。
