Hughes M S, Marsh J N, Wickline S A, McCarthy J E
Washington University School of Medicine, Washington University in St. Louis, St. Louis, Missouri 63110.
Department of Mathematics, Washington University in St. Louis, St. Louis, Missouri 63110.
J Acoust Soc Am. 2015 Jan;137(1):501. doi: 10.1121/1.4904531.
Previous results on the use of joint entropy for detection of targeted nanoparticles accumulating in the neovasculature of MDA435 tumors [Fig. 7 of M. S. Hughes et al., J. Acoust. Soc. Am. 133, 283-300 (2013)] are extended, with sensitivity improving by nearly another factor of 2. This result is obtained using a "quasi-optimal" reference waveform in the computation of the joint entropy imaging technique used to image the accumulating nanoparticles.
先前关于使用联合熵检测在MDA435肿瘤新生血管中聚集的靶向纳米颗粒的研究结果[M.S.休斯等人，《美国声学学会杂志》133, 283 - 300 (2013)中的图7]得到了扩展，灵敏度提高了近2倍。该结果是在用于对聚集纳米颗粒进行成像的联合熵成像技术计算中使用“准最优”参考波形获得的。
