Mazur A, Gueux E, Rémésy C, Demigné C, Rayssiguier Y
Institut National de la Recherche Agronomique, Laboratoire des Maladies Métaboliques, Ceyrat, France.
Magnes Res. 1989 Sep;2(3):189-92.
Because of the possible influence of obesity and insulin levels on magnesium metabolism, we have examined plasma and red blood cell (RBC) Mg in Zucker rats. There were reduced plasma and RBC Mg levels in Zucker rats compared with Wistar rats, and phenotype differences in Zucker rats. In obese rats, a high fibre diet reduced body weight, hyperinsulinaemia and hyperlipaemia and returned the plasma Mg concentration toward normal. However RBC levels were significantly lower than in lean rats of the same strain. The significance of the altered Mg concentration in obese Zucker rats may have metabolic implications and needs further study.
由于肥胖和胰岛素水平可能对镁代谢产生影响，我们检测了Zucker大鼠的血浆和红细胞镁含量。与Wistar大鼠相比，Zucker大鼠的血浆和红细胞镁含量降低，且Zucker大鼠存在表型差异。在肥胖大鼠中，高纤维饮食可降低体重、高胰岛素血症和高脂血症，并使血浆镁浓度恢复正常。然而，红细胞水平显著低于同一品系的瘦大鼠。肥胖Zucker大鼠镁浓度改变的意义可能具有代谢影响，需要进一步研究。
