School of Public Health, Curtin Health Innovation Research Institute, ATN Centre for Metabolic Fitness, Curtin University of Technology, GPO Box U1987, Perth, WA, Australia 6485.
Br J Nutr. 2011 Jan;105(1):90-100. doi: 10.1017/S0007114510003132. Epub 2010 Aug 23.
Optimum levels and types of dietary fibre that provide the greatest beneficial effects on metabolic syndrome risk factors in overweight and obese individuals have yet to be determined in clinical trials. The present parallel design study compared the effects of fibre intake from a healthy diet v. a fibre supplement (psyllium) or a healthy diet plus fibre supplement on fasting lipids, glucose, insulin and body composition. Overweight/obese adults were randomised to either control (with placebo), fibre supplement (FIB), healthy eating plus placebo (HLT) or healthy eating plus fibre supplement (HLT-FIB). There was a significant increase in fibre intake in HLT-FIB, HLT and FIB groups up to 59, 31 and 55 g, respectively, at 12 weeks when compared to control (20 g). Weight, BMI and % total body fat were significantly reduced in FIB and HLT-FIB groups, with weight and BMI significantly reduced in the HLT group compared with control at 12 weeks. HLT-FIB and HLT groups had significant reductions in TAG and insulin compared with control at 6 and 12 weeks, and in insulin compared with the FIB group at 12 weeks. The HLT-FIB, HLT and FIB groups all had significant reductions in total cholesterol and LDL-cholesterol compared with control after 6 and 12 weeks. The present study demonstrated that simply adding psyllium fibre supplementation to a normal diet was sufficient to obtain beneficial effects in risk factors. However, a high-fibre diet consisting of a psyllium supplement plus fibre from a healthy diet provided the greatest improvements in metabolic syndrome risk factors.
在临床试验中，尚未确定能为超重和肥胖个体的代谢综合征风险因素提供最大有益效果的最佳膳食纤维水平和类型。本平行设计研究比较了膳食纤维摄入量来自健康饮食与膳食纤维补充剂（车前子壳）或健康饮食加膳食纤维补充剂对空腹血脂、血糖、胰岛素和身体成分的影响。超重/肥胖成年人被随机分配至对照组（安慰剂）、膳食纤维补充剂组（FIB）、健康饮食加安慰剂组（HLT）或健康饮食加膳食纤维补充剂组（HLT-FIB）。与对照组（20 克）相比，12 周时 HLT-FIB、HLT 和 FIB 组的膳食纤维摄入量分别显著增加了 59、31 和 55 克。与对照组相比，FIB 和 HLT-FIB 组的体重、BMI 和总身体脂肪百分比显著降低，HLT 组在 12 周时体重和 BMI 也显著降低。与对照组相比，HLT-FIB 和 HLT 组在 6 周和 12 周时 TAG 和胰岛素显著降低，在 12 周时胰岛素与 FIB 组相比显著降低。与对照组相比，HLT-FIB、HLT 和 FIB 组在 6 周和 12 周时总胆固醇和 LDL-胆固醇均显著降低。本研究表明，仅在正常饮食中添加车前子壳纤维补充剂就足以获得风险因素的有益效果。然而，由车前子壳补充剂和健康饮食中的纤维组成的高纤维饮食在代谢综合征风险因素方面提供了最大的改善。
