Ohmuro Noriyuki, Matsumoto Kazunori, Katsura Masahiro, Obara Chika, Kikuchi Tatsuo, Hamaie Yumiko, Sakuma Atsushi, Iizuka Kunio, Ito Fumiaki, Matsuoka Hiroo
Department of Psychiatry, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.
Department of Psychiatry, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan; Department of Preventive Psychiatry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.
Schizophr Res. 2015 Mar;162(1-3):67-73. doi: 10.1016/j.schres.2015.01.008. Epub 2015 Jan 22.
Cognitive deficits and a high prevalence of depressive symptoms have been reported in at-risk mental state (ARMS) for psychosis, but the relationships between these variables remain unclear. The Brief Assessment of Cognition in Schizophrenia (BACS) was administered to 50 individuals with ARMS, 50 with first-episode psychosis (FEP), and 30 healthy controls (HC). Clinical symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Beck Depression Inventory-2nd edition (BDI-II). Composite z-scores in BACS were compared between the three groups. Pearson correlations between composite z-scores on the BACS and indices of clinical symptoms were compared in the ARMS and FEP groups. The mean composite z-scores on the BACS for the ARMS (-2.82) and FEP (-2.85) groups were significantly lower than the HC group (P<0.001); no differences between the ARMS and FEP groups emerged (P=0.995). Cognitive deficits and depressive symptoms were significantly correlated in the ARMS group (PANSS depression: r=-0.36, P=0.010; BDI-II: r=-0.34, P=0.02), while the correlation between cognitive deficits and negative symptoms was significant in the FEP group (r=-0.46, P=0.001) and approached significance in the ARMS group (r=-0.25, P=0.08). The correlation between cognitive deficits and depressive symptoms significantly differed between the ARMS and FEP groups (PANSS depression: Z=2.50, P=0.012; BDI-II: Z=1.96, P=0.0499). Thus, a relationship between cognitive deficits and depression appears to be specific to ARMS compared to FEP.
已有报道称，处于精神病高危精神状态（ARMS）的人群存在认知缺陷且抑郁症状患病率较高，但这些变量之间的关系仍不明确。对50名处于ARMS状态的个体、50名首发精神病（FEP）患者和30名健康对照者（HC）进行了精神分裂症认知简短评估（BACS）。通过阳性和阴性症状量表（PANSS）和贝克抑郁量表第二版（BDI-II）评估临床症状。比较了三组之间BACS的综合z分数。比较了ARMS组和FEP组中BACS综合z分数与临床症状指标之间的Pearson相关性。ARMS组（-2.82）和FEP组（-2.85）的BACS平均综合z分数显著低于HC组（P<0.001）；ARMS组和FEP组之间未发现差异（P=0.995）。ARMS组中认知缺陷与抑郁症状显著相关（PANSS抑郁：r=-0.36，P=0.010；BDI-II：r=-0.34，P=0.02），而FEP组中认知缺陷与阴性症状显著相关（r=-0.46，P=0.001），ARMS组接近显著相关（r=-0.25，P=0.08）。ARMS组和FEP组之间认知缺陷与抑郁症状的相关性显著不同（PANSS抑郁：Z=2.50，P=0.012；BDI-II：Z=1.96，P=0.0499）。因此，与FEP相比，认知缺陷与抑郁之间的关系似乎是ARMS所特有的。
