IQGAPs协调从细胞膜到细胞核的细胞信号传导。
IQGAPs choreograph cellular signaling from the membrane to the nucleus.
作者信息
Smith Jessica M, Hedman Andrew C, Sacks David B
机构信息
Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA.
Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Building 10, Room 2C306, Bethesda, MD 20892, USA.
出版信息
Trends Cell Biol. 2015 Mar;25(3):171-84. doi: 10.1016/j.tcb.2014.12.005. Epub 2015 Jan 21.
Abstract
Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1 have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been identified, implicating IQGAP1 as a critical integrator of cellular signaling pathways. Initial research established functions for IQGAP1 in cell-cell adhesion, cell migration, and cell signaling. Recent studies have revealed additional IQGAP1 binding partners, expanding the biological roles of IQGAP1. These include crosstalk between signaling cascades, regulation of nuclear function, and Wnt pathway potentiation. Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1. Summarized here are recent observations that enhance our understanding of IQGAP proteins in the integration of diverse signaling pathways.
摘要
自1994年被发现以来，支架蛋白IQGAP1的已知细胞功能已大幅扩展。已鉴定出100多种与IQGAP1相互作用的独特蛋白质，这表明IQGAP1是细胞信号通路的关键整合者。最初的研究确定了IQGAP1在细胞间粘附、细胞迁移和细胞信号传导中的功能。最近的研究揭示了更多与IQGAP1结合的伙伴，扩展了IQGAP1的生物学作用。这些作用包括信号级联之间的串扰、核功能的调节以及Wnt通路的增强。对IQGAP2和IQGAP3同源物的研究表明它们具有独特的功能，其中一些功能与IQGAP1不同。本文总结了最近的一些观察结果，这些结果加深了我们对IQGAP蛋白在整合多种信号通路方面的理解。
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The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.Cdc42 鸟嘌呤核苷酸交换因子 FGD6 协调破骨细胞的细胞极性和内体膜回收。
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