Hogan MaCalus V, Kawakami Yohei, Murawski Christopher D, Fu Freddie H
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A..
Arthroscopy. 2015 May;31(5):971-9. doi: 10.1016/j.arthro.2014.11.026. Epub 2015 Jan 21.
The use of musculoskeletal bioengineering and regenerative medicine applications in orthopaedic surgery has continued to evolve. The aim of this systematic review was to address tissue-engineering strategies for knee ligament reconstruction.
A systematic review of PubMed/Medline using the terms "knee AND ligament" AND "tissue engineering" OR "regenerative medicine" was performed. Two authors performed the search, independently assessed the studies for inclusion, and extracted the data for inclusion in the review. Both preclinical and clinical studies were reviewed, and the articles deemed most relevant were included in this article to provide relevant basic science and recent clinical translational knowledge concerning "tissue-engineering" strategies currently used in knee ligament reconstruction.
A total of 224 articles were reviewed in our initial PubMed search. Non-English-language studies were excluded. Clinical and preclinical studies were identified, and those with a focus on knee ligament tissue-engineering strategies including stem cell-based therapies, growth factor administration, hybrid biomaterial, and scaffold development, as well as mechanical stimulation modalities, were reviewed.
The body of knowledge surrounding tissue-engineering strategies for ligament reconstruction continues to expand. Presently, various tissue-engineering techniques have some potential advantages, including faster recovery, better ligamentization, and possibly, a reduction of recurrence. Preclinical research of these novel therapies continues to provide promising results. There remains a need for well-designed, high-powered comparative clinical studies to serve as a foundation for successful translation into the clinical setting going forward.
Level IV, systematic review of Level IV studies.
肌肉骨骼生物工程和再生医学在骨科手术中的应用不断发展。本系统评价旨在探讨膝关节韧带重建的组织工程策略。
使用“膝关节 AND 韧带”以及“组织工程”或“再生医学”等术语对 PubMed/Medline 进行系统评价。两名作者进行检索，独立评估纳入研究，并提取纳入综述的数据。对临床前和临床研究均进行了综述，本文纳入了认为最相关的文章，以提供有关目前用于膝关节韧带重建的“组织工程”策略的相关基础科学和近期临床转化知识。
在我们最初的 PubMed 检索中，共审查了224篇文章。排除非英语研究。确定了临床和临床前研究，并对那些侧重于膝关节韧带组织工程策略的研究进行了综述，这些策略包括基于干细胞的疗法、生长因子给药、混合生物材料和支架开发，以及机械刺激方式。
围绕韧带重建组织工程策略的知识体系不断扩展。目前，各种组织工程技术具有一些潜在优势，包括恢复更快、韧带化更好，以及可能降低复发率。这些新疗法的临床前研究继续提供有希望的结果。仍然需要精心设计、强有力的比较临床研究，为今后成功转化为临床应用奠定基础。
IV 级，IV 级研究的系统评价。
