Yoo Ki Deok, Jun Dae Won, Lee Kang Nyeong, Lee Hang Lak, Lee Oh Young, Yoon Byung Chul, Choi Ho Soon
Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
Department of Internal Medicine, Hanyang University, College of Medicine, Seoul, Republic of Korea.
Dig Liver Dis. 2015 Apr;47(4):303-8. doi: 10.1016/j.dld.2014.12.014. Epub 2015 Jan 3.
Aminotransferase activity is a surrogate marker of liver injury showing strong correlations with obesity and metabolic syndrome. However, elevated aminotransferase activity is not uncommon in non-obese and non-alcoholic patients in clinical practice.
To examine the relationship between sarcopenia and aminotransferase activity in a large population-based cohort.
Data from the Korean National Health and Nutrition Examinations were used. A total of 13,431 subjects were included. A whole-body dual X-ray absorptiometry scan was performed on each patient to measure total and regional muscle mass. Appendicular skeletal muscle mass indices were also obtained.
The prevalence of sarcopenia was significantly higher in the group with elevated aminotransferase levels than in the normal liver enzyme group (males: 26.5% vs. 16.9%; females: 38.3% vs. 22.1%, p<0.05). The skeletal muscle index was negatively correlated with most cardiometabolic risk factors, including fasting glucose and cholesterol levels. The frequency of elevated aminotransferase increased in male patients with sarcopenia after adjusting for potential confounding factors including age, body mass index, fasting glucose level, dietary, and exercise habits. However, the correlation was no longer observed in women after adjusting for body mass index.
Sarcopenia is a risk factor for elevated aminotransferase in men, independently of body mass index, dietary habits, and physical activity.
转氨酶活性是肝损伤的替代标志物，与肥胖和代谢综合征密切相关。然而，在临床实践中，非肥胖和非酒精性患者中转氨酶活性升高并不罕见。
在一个基于人群的大型队列中研究肌肉减少症与转氨酶活性之间的关系。
使用韩国国家健康与营养检查的数据。共纳入13431名受试者。对每位患者进行全身双能X线吸收测定扫描，以测量全身和局部肌肉量。还获得了四肢骨骼肌量指数。
转氨酶水平升高组的肌肉减少症患病率显著高于正常肝酶组（男性：26.5%对16.9%；女性：38.3%对22.1%，p<0.05）。骨骼肌指数与大多数心血管代谢危险因素呈负相关，包括空腹血糖和胆固醇水平。在调整了年龄、体重指数、空腹血糖水平、饮食和运动习惯等潜在混杂因素后，肌肉减少症男性患者转氨酶升高的频率增加。然而，在调整体重指数后，女性中不再观察到这种相关性。
肌肉减少症是男性转氨酶升高的危险因素，独立于体重指数、饮食习惯和体力活动。
