Geriatric Center and Department of Family Medicine, Myongji Hospital, Kwangdong University College of Medicine, Gyeonggi-Do, Republic of Korea.
Arch Gerontol Geriatr. 2013 May-Jun;56(3):472-7. doi: 10.1016/j.archger.2012.12.009. Epub 2013 Jan 6.
Although a variety of studies have reported the association between age related changes in muscle mass and the functional impairments of the elderly, few have reported on the modifiable lifestyle factors that are related to sarcopenia. Three thousand five hundred ninety-eight men in nationally representative cross-sectional, population-representative sampled survey using data from the KNHANES IV aged 19 years and older who completed a body composition using a dual energy X-ray absorptiometry (DXA) were measured. To determine whether there are any associations between physical activities, nutritional status and sarcopenia were examined in 1156 men among those over 60 years of age. Appendicular skeletal muscle mass (ASM) was calculated as the sum of skeletal muscle in the arms and legs. Sarcopenia was defined as the ASM/Ht(2) of less than two standard deviations (SD) below the sex-specific normal mean for the younger reference group. The prevalence of sarcopenia in Korean men aged 60 years and older was 9.9%. Sarcopenia was negatively associated with the third quartile (OR=0.40, 95% CI=0.20-0.80) and fourth quartile of PA (OR=0.24, 95% CI=0.11-0.52), and negatively associated with the highest quartile of protein intake (OR=0.32, 95% CI=0.14-0.76). In logistic regression models, sarcopenia was negatively associated with walking PA (OR=0.49, 95% CI=0.29-0.83) after an adjustment for age, smoking habits, alcohol drinking, family income, education status and protein intake. Sarcopenia was associated with PA, especially walking PA.
尽管许多研究报告了肌肉质量与老年人功能障碍相关的年龄相关变化,但很少有研究报告与肌肉减少症相关的可改变的生活方式因素。本研究使用 KNHANES IV 中 19 岁及以上的 3598 名男性的横断面、具有代表性的人群抽样调查数据,这些人使用双能 X 射线吸收法(DXA)完成了身体成分测量。在这些 60 岁以上的人中,有 1156 名男性进行了身体活动、营养状况与肌肉减少症之间的关系的检测。四肢骨骼肌质量(ASM)被定义为手臂和腿部骨骼肌肉的总和。肌肉减少症定义为四肢骨骼肌质量/身高(2)低于年轻参考组的性别特异性正常平均值两个标准差以下。韩国 60 岁及以上男性肌肉减少症的患病率为 9.9%。肌肉减少症与第三四分位(OR=0.40,95%CI=0.20-0.80)和第四四分位的身体活动(OR=0.24,95%CI=0.11-0.52)呈负相关,与最高四分位的蛋白质摄入量(OR=0.32,95%CI=0.14-0.76)呈负相关。在逻辑回归模型中,在调整年龄、吸烟习惯、饮酒、家庭收入、教育程度和蛋白质摄入量后,肌肉减少症与步行身体活动(OR=0.49,95%CI=0.29-0.83)呈负相关。肌肉减少症与身体活动有关,特别是与步行身体活动有关。