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肌球蛋白台面与人类肥厚型心肌病分子基础的一种可能统一假说。

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy.

作者信息

Spudich James A

机构信息

*Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, U.S.A.

出版信息

Biochem Soc Trans. 2015 Feb;43(1):64-72. doi: 10.1042/BST20140324.

DOI:10.1042/BST20140324
PMID:25619247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349527/
Abstract

No matter how many times one explores the structure of the myosin molecule, there is always something new to discover. Here, I describe the myosin mesa, a structural feature of the motor domain that has the characteristics of a binding domain for another protein, possibly myosin-binding protein C (MyBP-C). Interestingly, many well-known hypertrophic cardiomyopathy (HCM) mutations lie along this surface and may affect the putative interactions proposed here. A potential unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy is discussed here. It involves increased power output of the cardiac muscle as a result of HCM mutations causing the release of inhibition by myosin binding protein C.

摘要

无论对肌球蛋白分子的结构进行多少次探索，总会有新的发现。在此，我描述了肌球蛋白台面，这是运动结构域的一个结构特征，具有作为另一种蛋白质（可能是肌球蛋白结合蛋白C，即MyBP - C）结合结构域的特性。有趣的是，许多著名的肥厚型心肌病（HCM）突变都位于这个表面，可能会影响本文提出的假定相互作用。本文讨论了关于人类肥厚型心肌病分子基础的一个潜在统一假说。它涉及由于HCM突变导致肌球蛋白结合蛋白C解除抑制从而使心肌功率输出增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/e318db1a03f7/nihms666118f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/c77202bc1405/nihms666118f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/f37920eb3c0a/nihms666118f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/c564fa63d6ff/nihms666118f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/89984e0c94ff/nihms666118f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/764c966c3f3f/nihms666118f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/e318db1a03f7/nihms666118f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/c77202bc1405/nihms666118f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/9843ce5a13b1/nihms666118f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/f37920eb3c0a/nihms666118f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/c564fa63d6ff/nihms666118f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/89984e0c94ff/nihms666118f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/764c966c3f3f/nihms666118f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0235/4349527/e318db1a03f7/nihms666118f7.jpg

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