Li Pingping, Qiu Tangmeng, Qin Chao
Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China (mainland).
Department of Neurology, Guangxi Medical University, Nanning, Guangxi, China (mainland).
Med Sci Monit. 2015 Jan 19;21:231-8. doi: 10.12659/MSM.892253.
A growing number of studies on the associations between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox C242T polymorphism and risk of ischemic cerebrovascular disease have recently been published, but the results remain inconsistent.
MATERIAL/METHODS: We performed an updated meta-analysis to evaluate this association. Eight case-control studies were included, involving 2045 cases and 2102 controls. Heterogeneity was assessed by the Q test and the I2 statistic. Begg and Egger's tests were conducted to evaluate publication bias. Odds ratio (OR) was tested to identify the associations.
Significant associations between p22phox gene C242T polymorphism and ischemic cerebrovascular disease (ICVD) risk were observed in the allelic genetic model (OR=1.33, 95% confidence interval [CI] 1.00-1.77, p=0.048). No statistical significant association was found in the dominant model (OR=0.74, 95% CI 0.54-1.02, p=0.064) and recessive model (OR=1.40, 95% CI 0.89-2.19, p=0.146). Subgroup analysis showed an association in European populations for recessive model (OR=2.13, 95% CI 1.06-4.26, p=0.034) and no significant evidence of association in Asian populations was found (dominant model: OR=0.64, 95% CI 0.41-1.00, p=0.05; recessive model: OR=0.98, 95% CI 0.53-1.81, p=0.948; allelic model: OR=1.51, 95% CI 0.98-2.32, p=0.061).
p22phox gene C242T polymorphism was associated with ICVD risk in the allelic genetic model, as well as in European populations for recessive model. No evidence showed association between p22phox gene C242T polymorphism and ICVD risk in the dominant model and recessive model. Furthermore, no association existed in Asian populations for any of the 3 genetic models and European populations in the dominant model and allelic model.
近年来，关于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶p22phox C242T基因多态性与缺血性脑血管病风险之间关联的研究日益增多，但结果仍不一致。
材料/方法：我们进行了一项更新的荟萃分析来评估这种关联。纳入了8项病例对照研究，涉及2045例病例和2102例对照。通过Q检验和I2统计量评估异质性。采用Begg和Egger检验评估发表偏倚。通过比值比（OR）检验来确定关联。
在等位基因遗传模型中观察到p22phox基因C242T多态性与缺血性脑血管病（ICVD）风险之间存在显著关联（OR = 1.33，95%置信区间[CI] 1.00 - 1.77，p = 0.048）。在显性模型（OR = 0.74，95% CI 0.54 - 1.02，p = 0.064）和隐性模型（OR = 1.40，95% CI 0.89 - 2.19，p = 0.146）中未发现统计学显著关联。亚组分析显示，在欧洲人群的隐性模型中存在关联（OR = 2.13，95% CI 1.06 - 4.26，p = 0.034），而在亚洲人群中未发现显著关联证据（显性模型：OR = 0.64，95% CI 0.41 - 1.00，p = 0.05；隐性模型：OR = 0.98，95% CI 0.53 - 1.81，p = 0.948；等位基因模型：OR = 1.51，95% CI 0.98 - 2.32，p = 0.061）。
在等位基因遗传模型以及欧洲人群的隐性模型中，p22phox基因C242T多态性与ICVD风险相关。在显性模型和隐性模型中，没有证据表明p22phox基因C242T多态性与ICVD风险之间存在关联。此外，在亚洲人群的三种遗传模型以及欧洲人群的显性模型和等位基因模型中均未发现关联。
