Department of Epidemiology and Health Statistics, Shandong University, PR China.
Thromb Res. 2010 May;125(5):e197-201. doi: 10.1016/j.thromres.2010.01.001. Epub 2010 Jan 25.
The C242T polymorphism of p22phox gene (rs4673) has been linked to the reduced coronary artery disease (CAD) risk, but results in the published literatures are controversial. A meta-analysis was performed to assess the effect of this polymorphism on the CAD risk.
A comprehensive search was conducted to identify all studies on the association of p22phox gene C242T polymorphism with CAD risk. The fixed or random effect pooled measure was selected based on the homogeneity test among studies. Heterogeneity among studies was evaluated using Q test and the I(2) of Higgins and Thompson. Meta-regression was used to explore the sources of between-study heterogeneity. Publication bias was estimated using modified Egger's linear regression test proposed by Harbord etal.
We identified 15 published articles including 6273 CAD cases and 5045 controls. In this studied overall and non-Asian populations, we didn't found any significant association of p22phox gene C242T polymorphism with CAD in any of codominant, dominant, and recessive models. Only in Asian population, both fixed effect model (FEM) and random effect model (REM) indicated the significant protective effect both in codominant (FEM: OR=0.771, 95%CI: 0.681-0.873; REM: OR=0.751, 95%CI: 0.607-0.930) and dominant (FEM: OR=0.714, 95%CI: 0.621-0.822; REM: OR=0.694, 95%CI: 0.538-0.895) models with strong evidence for between-study heterogeneity (I(2)=52.6% for codominant and I(2)=56.5% for dominant), but not in recessive model. No evidence of publication bias was detected.
The results suggested a significant heterogeneity across ethnicities about the relationship between the T allele of p22phox gene C242T polymorphism and reduced CAD risk, with a significant protective effect only in Asian population that needs to be confirmed by further studies.
p22phox 基因（rs4673）的 C242T 多态性与冠心病（CAD）风险降低有关，但已发表的研究结果存在争议。进行了荟萃分析以评估该多态性对 CAD 风险的影响。
全面检索了所有关于 p22phox 基因 C242T 多态性与 CAD 风险关联的研究。根据研究之间的同质性检验，选择固定或随机效应合并度量。使用 Q 检验和 Higgins 和 Thompson 的 I(2)评估研究之间的异质性。使用 Harbord 等人提出的改良 Egger 线性回归检验估计发表偏倚。
我们确定了 15 篇已发表的文章，其中包括 6273 例 CAD 病例和 5045 例对照。在这项总体研究和非亚洲人群中，我们没有发现 p22phox 基因 C242T 多态性与 CAD 之间存在任何显著关联，无论是在显性、显性还是隐性模型中。仅在亚洲人群中，固定效应模型（FEM）和随机效应模型（REM）均表明显性模型（FEM：OR=0.771，95%CI：0.681-0.873；REM：OR=0.751，95%CI：0.607-0.930）和显性模型（FEM：OR=0.714，95%CI：0.621-0.822；REM：OR=0.694，95%CI：0.538-0.895）均具有显著的保护作用，且存在强异质性证据（显性模型的 I(2)=52.6%，显性模型的 I(2)=56.5%），但在隐性模型中没有。未发现发表偏倚的证据。
结果表明，p22phox 基因 C242T 多态性与 CAD 风险降低之间的关系在种族之间存在显著的异质性，仅在亚洲人群中具有显著的保护作用，需要进一步研究证实。
