能够实现甘露糖介导的靶向癌细胞药物递送的可生物降解胶束。
Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.
作者信息
Yin Lichen, Chen Yongbing, Zhang Zhonghai, Yin Qian, Zheng Nan, Cheng Jianjun
机构信息
Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, Jiangsu, China.
出版信息
Macromol Rapid Commun. 2015 Mar;36(5):483-9. doi: 10.1002/marc.201400650. Epub 2015 Jan 23.
Abstract
A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.
摘要
一种靶向胶束药物递送系统是由一种生物相容性和可生物降解的两亲性聚酯聚（Lac-OCA）-b-（聚（Tyr（炔基）-OCA）-g-甘露糖）（PLA-b-（PTA-g-甘露糖））开发而成，该聚酯通过O-羧基酸酐（OCA）的可控开环聚合和高效的“点击”化学合成。阿霉素（DOX）是一种典型的亲脂性抗癌药物，可有效包封于胶束中，而甘露糖部分使胶束能够主动靶向特异性表达甘露糖受体的癌细胞，从而提高药物的抗癌效率。该胶束系统完全由可生物降解和生物相容性聚酯组成，在靶向药物递送和癌症治疗方面显示出有前景的潜力。
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