抗癌喜树碱——具有易水解连接基的聚乳酸纳米共轭物
Anticancer Camptothecin--Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.
作者信息
Yin Qian, Tong Rong, Yin Lichen, Fan Timothy M, Cheng Jianjun
机构信息
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
Polym Chem. 2014;5(5):1581-1585. doi: 10.1039/C3PY01245J.
Abstract
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT--PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired physicochemical properties and showed enhanced therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
摘要
我们报道了一种通过可控聚合方法，利用易水解的氨基酯连接子将喜树碱（CPT）与聚乳酸（PLA）的末端羧基相连的策略。所得到的CPT-PLA缀合物能够自组装成具有所需物理化学性质的50-100纳米大小的纳米缀合物（NCs），并且对C57BL/6小鼠诱导的Lewis肺癌（LLC）显示出增强的治疗效果。
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