Yin Qian, Tong Rong, Yin Lichen, Fan Timothy M, Cheng Jianjun
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Polym Chem. 2014;5(5):1581-1585. doi: 10.1039/C3PY01245J.
We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT--PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desired physicochemical properties and showed enhanced therapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
我们报道了一种通过可控聚合方法，利用易水解的氨基酯连接子将喜树碱（CPT）与聚乳酸（PLA）的末端羧基相连的策略。所得到的CPT-PLA缀合物能够自组装成具有所需物理化学性质的50-100纳米大小的纳米缀合物（NCs），并且对C57BL/6小鼠诱导的Lewis肺癌（LLC）显示出增强的治疗效果。
