Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
Org Lett. 2015 Feb 6;17(3):544-7. doi: 10.1021/ol5035518. Epub 2015 Jan 26.
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.
本文提出了一种实用的脱氟方法，使用新型脱氟试剂 PhenoFluorMix，这是一种 N,N'-1,3-双(2,6-二异丙基苯基)氯代咪唑𬭩氯化物和 CsF 的混合物。PhenoFluorMix 克服了 PhenoFluor 水解相关的挑战。PhenoFluorMix 不会水解，易于获得 10 克规模，并且可以在空气中储存。在本文中，我们证明了该试剂的实用性，并展示了各种酚类和杂环化合物的脱氟反应。
