Kahya Eren Nihan, Harman Ece, Dolek Devrim, Tütüncüoğlu Aliye Pelin, Emren Sadık Volkan, Levent Fatih, Korkmaz Gülten, Yakar Tülüce Selcen, Nazlı Cem
Department of Cardiology, İzmir Katip Çelebi University Ataturk Training and Research Hospital, İzmir, Turkey.
Department of Endocrinology, İzmir Katip Çelebi University Ataturk Training and Research Hospital, İzmir, Turkey.
Turk Kardiyol Dern Ars. 2014 Dec;42(8):733-40. doi: 10.5543/tkda.2014.53384.
Hypertension is a common co-morbidity in patients with type 2 diabetes. Management of hypertension is of paramount importance in reducing macro- and microvascular complications of diabetes. The aim of this study is to determine the rate of blood pressure control (<140/85 mmHg) in diabetic patients with hypertension, and to evaluate the prescribing pattern of antihypertensive medications.
This was a prospective, cross-sectional, observational study conducted in a tertiary centre in Turkey. Of 707 patients with diabetes, 500 hypertensive patients were evaluated to determine control of hypertension and treatment attitudes. Logistic regression analysis was used to evaluate the likelihood of prescription of each class of antihypertensive medications for the presence of macro- and microvascular complications.
Most of the patients (95%) were on antihypertensive therapy. Only 41% achieved target blood pressure values (<140/85 mmHg). Renin angiotensin system (RAS) blockers were the most frequently (82.4%) prescribed antihypertensive agents, and a combination of RAS blockers and diuretics were the most commonly preferred combination therapy. Most of the patients were on 1 antihypertensive drug or a combination of 2 drugs (39.5% and 44.7%, respectively). Patients with coronary artery disease were more likely to receive beta blockers (Odds ratio=3.6, 95% confidence interval=2.3-5.6; p<0.001).
Although most of the diabetic hypertensive patients were on hypertensive therapy, more than half had uncontrolled blood pressure.
高血压是2型糖尿病患者常见的合并症。控制高血压对于减少糖尿病的大血管和微血管并发症至关重要。本研究的目的是确定高血压糖尿病患者的血压控制率（<140/85 mmHg），并评估抗高血压药物的处方模式。
这是一项在土耳其一家三级中心进行的前瞻性横断面观察性研究。在707例糖尿病患者中，对500例高血压患者进行评估，以确定高血压控制情况和治疗态度。采用逻辑回归分析评估各类抗高血压药物因存在大血管和微血管并发症而被处方的可能性。
大多数患者（95%）接受抗高血压治疗。只有41%的患者达到目标血压值（<140/85 mmHg）。肾素血管紧张素系统（RAS）阻滞剂是最常被处方的抗高血压药物（82.4%），RAS阻滞剂和利尿剂联合使用是最常用的联合治疗方案。大多数患者服用1种抗高血压药物或2种药物联合使用（分别为39.5%和44.7%）。冠心病患者更有可能接受β受体阻滞剂治疗（比值比=3.6，95%置信区间=2.3-5.6；p<0.001）。
虽然大多数糖尿病高血压患者接受了高血压治疗，但超过一半的患者血压未得到控制。
