King B H, Brazell C, Dourish C T, Middlemiss D N
UCLA Neuropsychiatric Institute 90024.
Neurosci Lett. 1989 Oct 23;105(1-2):174-6. doi: 10.1016/0304-3940(89)90032-3.
The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C receptor subtype to increase ACTH.
研究了血清素激动剂MK - 212对大鼠血浆促肾上腺皮质激素（ACTH）的影响。MK - 212显著提高了血浆ACTH水平，且这种作用可被5 - HT1C拮抗剂美舒麦角和米替戈林阻断，但不能被螺哌隆、酮色林或（-）-吲哚洛尔阻断。结果表明，MK - 212通过激活5 - HT1C受体亚型来增加ACTH。
