Glennon R A, Pierson M E, McKenney J D
Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
Pharmacol Biochem Behav. 1988 Jan;29(1):197-9. doi: 10.1016/0091-3057(88)90296-1.
Using standard operant procedures with rats trained to discriminate the serotonin (5-HT) agonist 1-(3-trifluoromethylphenyl)piperazine (TFMPP) (0.5 mg/kg) from saline, tests of stimulus generalization and stimulus antagonism were conducted with propranolol, pindolol, and mesulergine. Neither propranolol nor mesulergine antagonized the TFMPP stimulus (pindolol was not evaluated as an antagonist). However, TFMPP-stimulus generalization occurred with all three agents. These results suggest that the TFMPP-stimulus may involve both a 5-HT1B and a 5-HT1C mechanism and further suggest that propranolol, pindolol, and mesulergine may be capable of acting as agonists at certain populations of serotonin receptors.
采用标准操作性程序，用经过训练以区分5-羟色胺（5-HT）激动剂1-（3-三氟甲基苯基）哌嗪（TFMPP）（0.5毫克/千克）和生理盐水的大鼠进行了刺激泛化和刺激拮抗试验，使用了普萘洛尔、吲哚洛尔和麦角乙脲。普萘洛尔和麦角乙脲均未拮抗TFMPP刺激（吲哚洛尔未作为拮抗剂进行评估）。然而，所有这三种药物均出现了TFMPP刺激泛化。这些结果表明，TFMPP刺激可能涉及5-HT1B和5-HT1C两种机制，并进一步表明普萘洛尔、吲哚洛尔和麦角乙脲可能能够在某些5-羟色胺受体群体上充当激动剂。
