Section of Nephrology and Hypertension, LSUHSC-NO, 1542 Tulane Avenue, Room 330A, New Orleans, LA, 70112, USA,
Curr Hypertens Rep. 2015 Feb;17(2):7. doi: 10.1007/s11906-014-0520-2.
There is a neglected epidemic of both obesity and metabolic syndrome in industrialized and unindustrialized countries all over the globe. Both conditions are associated with a high incidence of other serious pathologies, such as cardiovascular and renal diseases. In this article, we review the potential underlying mechanisms by which obesity and metabolic syndrome promote hypertension, including changes in cardiovascular-renal physiology induced by leptin, the sympathetic nervous system, the renin-angiotensin-aldosterone system, insulin resistance, free fatty acids, natriuretic peptides, and proinflammatory cytokines. We also discuss the potential underlying mechanisms by which obesity promotes other cardiovascular and renal conditions, as well as available nonpharmacologic and pharmacologic approaches for treating obesity-induced hypertension. The findings presented herein suggest that adipocytes may be a key regulator of cardiovascular and renal function.
在全球工业化和非工业化国家，肥胖症和代谢综合征都是被忽视的流行病。这两种情况都与其他严重疾病的高发率相关，如心血管和肾脏疾病。在本文中，我们回顾了肥胖症和代谢综合征导致高血压的潜在潜在机制，包括瘦素、交感神经系统、肾素-血管紧张素-醛固酮系统、胰岛素抵抗、游离脂肪酸、利钠肽和促炎细胞因子引起的心血管-肾脏生理学变化。我们还讨论了肥胖症促进其他心血管和肾脏疾病的潜在潜在机制，以及治疗肥胖症引起的高血压的可用非药物和药物方法。本文提出的研究结果表明，脂肪细胞可能是心血管和肾功能的关键调节者。
