Ono I, Ishiwata I, Nakaguchi T, Soma M, Tokita N, Ishiwata C, Mukai M, Ishikawa H
Mutual Aid Association, Suifu Hospital, Japan.
Hum Cell. 1989 Jun;2(2):173-80.
Serial heterotransplantation of human malignant fibrous histiocytoma (MFH) derived from tibia was attempted in BALB/c nu/nu mice, and HKMFH-nu transplantable tumor line was established. This line had the following biological properties. (1) Eighteen serial passages were carried out in 41 months. (2) Morphological changes of the grafts occurred in nude mice with serial passages: During the first 6 passages, histiological picture was consistent with the common type of MFH similar to that of the original tumor, then after the 7th passage, the myxoid type coexisted with the common type, and finally the myxoid type occupied the entire grafts to form large cysts. (3) The common type grafts grew more rapidly than the myxoid type grafts. (4) Granulocytosis (neutrophilia) was observed in mice bearing the common type tumor, but not in mice bearing the myxoid type tumor.
尝试将源自胫骨的人类恶性纤维组织细胞瘤（MFH）连续异种移植到BALB/c裸鼠中，并建立了HKMFH-nu可移植肿瘤系。该肿瘤系具有以下生物学特性。（1）在41个月内进行了18次连续传代。（2）随着传代次数增加，裸鼠体内移植物出现形态学变化：在前6次传代期间，组织学图像与原始肿瘤相似的常见类型MFH一致，然后在第7次传代后，黏液样型与常见型共存，最终黏液样型占据整个移植物形成大囊肿。（3）常见型移植物比黏液样型移植物生长更快。（4）在携带常见型肿瘤的小鼠中观察到粒细胞增多（中性粒细胞增多），但在携带黏液样型肿瘤的小鼠中未观察到。
