硝苯地平和维拉帕米对半胱氨酰白三烯诱导的绵羊子宫收缩的影响
[Effects of nifedipine and verapamil on cysteinyl leukotriene-induced contractions of the sheep uterus].
作者信息
Ledwozyw A, Kadziołka A
机构信息
Zakład Patofizjologii Wydziału Weterynaryjnego Akademii Rolniczej w Lublinie.
出版信息
Pol Arch Weter. 1989;29(1-2):189-200.
Both nifedipine and verapamil, the calcium channel blockers were tested to determine their anti-leukotriene properties in pig uterine strips. These drugs in concentrations ranging from 1.10(-7)M to 1.10(-5)M significantly attenuated the constrictor effects of cysteinyl leukotrienes in pig uterus. Thus, leukotrienes C4, D4 and E4 are dependent upon Ca2+ for their myotropic activity, an action non-competitively inhibited by the calcium channel blockers nifedipine and verapamil.
对钙通道阻滞剂硝苯地平和维拉帕米进行了测试，以确定它们在猪子宫条中的抗白三烯特性。这些药物浓度范围为1×10⁻⁷M至1×10⁻⁵M时，能显著减弱半胱氨酰白三烯对猪子宫的收缩作用。因此，白三烯C4、D4和E4的致肌活性依赖于Ca²⁺，这种作用可被钙通道阻滞剂硝苯地平和维拉帕米非竞争性抑制。
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